Though Ephraim was the younger, last born of Joseph, Jacob by YAHWEH’s direction chose him to receive the first born,s blessings. YAHWEH Has always chosen the least or weakest of us to do HIS great works in this earth. As HE did for Ephraim, HE chose Gideon (Judges 6:15), and HE chose Saul from the smallest tribe to rule over Israel (1 Samuel 9:21).
Genesis 48:17-22 Now when Joseph saw that his father laid his right hand on the head of Ephraim, it displeased him; so he took hold of his father’s hand to remove it from Ephraim’s head to Manasseh’s head. And Joseph said to his father, “Not so, my father, for this one is the firstborn; put your right hand on his head.” But his father refused and said, “I know, my son, I know. He also shall become a people, and he also shall be great; but truly his younger brother shall be greater than he, and his descendants shall become a multitude of nations.” So he blessed them that day, saying, “By you Israel will bless, saying, ‘May God make you as Ephraim and as Manasseh!’ ” And thus he set Ephraim before Manasseh. Then Israel said to Joseph, “Behold, I am dying, but God will be with you and bring you back to the land of your fathers. Moreover I have given to you one portion above your brothers, which I took from the hand of the Amorite with my sword and my bow.”
https://bible.com/bible/114/gen.48.17-22.NKJV
Judges 6:11-16 Now the Angel of the Lord came and sat under the terebinth tree which was in Ophrah, which belonged to Joash the Abiezrite, while his son Gideon threshed wheat in the winepress, in order to hide it from the Midianites. And the Angel of the Lord appeared to him, and said to him, “The Lord is with you, you mighty man of valor!” Gideon said to Him, “O my lord, if the Lord is with us, why then has all this happened to us? And where are all His miracles which our fathers told us about, saying, ‘Did not the Lord bring us up from Egypt?’ But now the Lord has forsaken us and delivered us into the hands of the Midianites.” Then the Lord turned to him and said, “Go in this might of yours, and you shall save Israel from the hand of the Midianites. Have I not sent you?” So he said to Him, “O my Lord, how can I save Israel? Indeed my clan is the weakest in Manasseh, and I am the least in my father’s house.” And the Lord said to him, “Surely I will be with you, and you shall defeat the Midianites as one man.”
https://bible.com/bible/114/jdg.6.11-16.NKJV
I Samuel 9:19-21 Samuel answered Saul and said, “I am the seer. Go up before me to the high place, for you shall eat with me today; and tomorrow I will let you go and will tell you all that is in your heart. But as for your donkeys that were lost three days ago, do not be anxious about them, for they have been found. And on whom is all the desire of Israel? Is it not on you and on all your father’s house?” And Saul answered and said, “Am I not a Benjamite, of the smallest of the tribes of Israel, and my family the least of all the families of the tribe of Benjamin? Why then do you speak like this to me?”
https://bible.com/bible/114/1sa.9.19-21.NKJV
Matthew 19:30 But many who are first will be last, and the last first.
https://bible.com/bible/114/mat.19.30.NKJV
1 Corinthians 1:26-29 Remember, dear brothers and sisters, that few of you were wise in the world’s eyes or powerful or wealthy when God called you. Instead, God chose things the world considers foolish in order to shame those who think they are wise. And he chose things that are powerless to shame those who are powerful. God chose things despised by the world, things counted as nothing at all, and used them to bring to nothing what the world considers important. As a result, no one can ever boast in the presence of God.
https://bible.com/bible/116/1co.1.26-29.NLT